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When I build using 4.2.3 in Visual Studio it will often say that *.mdb is in use build failed. I have tried a clean, deleting the file, etc. The only thing that seems to fix it is closing and relaunching Visual Studio after which I can get a couple builds out of it before it does it again...
I fixed this yesterday for the next release, 4.2.4. Unfortunately, restarting VS is the only workaround for now.
*** This bug has been marked as a duplicate of bug 5608 ***
Oh, it's caused by debugging. If you don't need debugging on a particular run, run without debugging: Ctrl-F5.